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Imfinzi (durvalumab) UK Prescribing Information
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  • Home | DUO-E (Imfinzi (durvalumab) & Lynparza (olaparib))
  • Dosing and administration| DUO-E (Imfinzi (durvalumab) & Lynparza (olaparib))
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Dosing and administration| DUO-E (Imfinzi (durvalumab) & Lynparza (olaparib))

Dosing and Admin

 

The addition of LYNPARZA® to IMFINZI® maintenance provides a convenient, twice-daily tablet treatment formulation for eligible patients with arEC

IMFINZI® + LYNPARZA® regimen

Recommended dosing for the IMFINZI® + LYNPARZA® + CP Regimen in patients with pMMR aEC

'Dosing and adminstration of Imfinzi + lynparza regimen for pMMR arEC 'Dosing and adminstration of Imfinzi + lynparza regimen for pMMR arEC

IMFINZI® + CP regimen

Recommended dosing for the IMFINZI® + LYNPARZA® + CP Regimen in patients with pMMR aEC

'Dosing and adminstration of Imfinzi regimen for dMMR arEC 'Dosing and adminstration of Imfinzi regimen for dMMR arEC

How to reduce Lynparza dosing for Imfinzi + lynparza regimen in pMMR arEC How to reduce Lynparza dosing for Imfinzi + lynparza regimen in pMMR arEC

*For concomitant administration with CY3PA inhibitors, or use in patients with hepatic or renal impairments, please consult the Lynparza 100 mg and 150 mg tablet Summary of Product Characteristics.

Please refer to the Imfinzi SmPC prior to prescribing for safety considerations to minimise the risks associated with its use1

Please refer to the Lynparza SmPC prior to prescribing for safety considerations to minimise the risks associated with its use3

  1. IMFINZI® (durvalumab) Summary of Product Characteristics.
  2. Westin SN et al. J Clin Oncol 2024;42:283–29. Supplementary appendix.
  3. LYNPARZA® (olaparib) Summary of Product Characteristics.
Indication
  • IMFINZI in combination with carboplatin and paclitaxel is indicated for the first-line treatment of adults with primary advanced or recurrent endometrial cancer who are candidates for systemic therapy, followed by treatment with:
    • IMFINZI as monotherapy in endometrial cancer that is mismatch repair deficient (dMMR)
    • IMFINZI in combination with olaparib in endometrial cancer that is mismatch repair proficient (pMMR).
  • Lynparza in combination with durvalumab is indicated for the maintenance treatment of adult patients with primary advanced or recurrent endometrial cancer that is mismatch repair proficient (pMMR) whose disease has not progressed on first-line treatment with durvalumab in combination with carboplatin and paclitaxel.

GB-68806 | DOP: September 2025

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to AstraZeneca by visiting https://contactazmedical.astrazeneca.com/ or by calling ‌‌‌0‌‌‌8‌‌‌‌‌0‌‌‌‌0‌‌‌ ‌‌7‌‌‌‌‌‌8‌‌‌3‌‌‌ ‌‌0‌‌‌‌‌0‌‌‌‌3‌‌‌‌3‌‌‌.

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