Welcome to this UK AstraZeneca produced and funded website

This website is intended for UK Healthcare Professionals only.

 

The website contains both promotional and non-promotional content.

 

If you are a patient or a carer of a patient prescribed an AstraZeneca product, please visit myazmed.co.uk

 

For any other UK residents please visit astrazeneca.co.uk

I am not a Healthcare Professional
Prescribing Information LYNPARZA (olaparib) United Kingdom
Adverse Event Reporting

This website is intended for UK Healthcare Professionals only. Other UK residents please visit astrazeneca.co.uk

These Lynparza website pages were funded and produced by AstraZeneca UK and MSD UK

AstraZeneca-logo
  • Our Medicines
    • Cardiovascular, Renal & Metabolism
      • ATTR Amyloidosis
        • WAINZUA®▼(eplontersen)
      • Chronic Kidney Disease (CKD)
        • FORXIGA® (dapagliflozin)
      • Heart Failure
        • FORXIGA® (dapagliflozin)
      • Hyperkalaemia
        • LOKELMA® (sodium zirconium cyclosilicate)
      • Type 2 Diabetes (T2D)
        • FORXIGA® (dapagliflozin)
    • Oncology
      • Breast Cancer
        • LYNPARZA® (olaparib)
        • TRUQAP®▼(capivasertib)
      • Bladder Cancer
        • IMFINZI® (durvalumab)
      • Endometrial Cancer
        • IMFINZI® (durvalumab)
        • LYNPARZA® (olaparib)
      • Gastrointestinal Cancer
        • IMFINZI® (durvalumab)
        • IMJUDO®▼(tremelimumab)
      • Lung Cancer
        • IMFINZI® (durvalumab)
        • TAGRISSO® (osimertinib)
      • Ovarian Cancer
        • LYNPARZA® (olaparib)
      • Prostate Cancer
        • LYNPARZA® (olaparib)
        • ZOLADEX® (goserelin)
    • Respiratory
      • Asthma
        • TEZSPIRE®▼ (tezepelumab)
        • SYMBICORT® (budesonide/formoterol)
      • Chronic Obstructive Pulmonary Disease(COPD)
        • TRIXEO AEROSPHERE® (formoterol fumarate dihydrate/glycopyrronium/budesonide)
        • BEVESPI® (glycopyrronium/formoterol fumarate dihydrate)
    • Vaccines
      • Flu
        • FLUENZ® nasal spray suspension (influenza vaccine, live attenuated, nasal)
  • Therapy Areas
    • Cardiovascular, Renal & Metabolism
      • ATTR Amyloidosis
      • Chronic Kidney Disease (CKD)
      • Heart Failure
      • Hyperkalaemia
      • Type 2 Diabetes (T2D)
    • Oncology
      • Breast Cancer
      • Bladder Cancer
      • Endometrial Cancer
      • Gastrointestinal Cancer
      • Lung Cancer
      • Ovarian Cancer
      • Prostate Cancer
    • Respiratory
      • Asthma
      • Chronic Obstructive Pulmonary Disease(COPD)
    • Vaccines
      • Flu
  • About us
    • AZ Commitment
  • Contact us
  • AstraZeneca UK
  • Lynparza
  • LYNPARZA® (olaparib) | Ovarian Cancer | AstraZeneca & MSD UK
  • LYNPARZA® (olaparib) | Dosing
  • Home
  • PAOLA-1
  • SOLO-1
  • HRD Testing
  • Dosing
  • Resources
LYNPARZA® (olaparib) | Dosing
Make HER first-line count in the maintenance setting in newly diagnosed aOC Make HER first-line count in the maintenance setting in newly diagnosed aOC

Lynparza + bevacizumab offers patients with HRD+ aOC the
chance to complete treatment after just 2 years1,2

  • Lynparza integrated 1L treatment
  • Monotherapy dosing
  • Lynparza + bevacizumab dosing
  • Flexible dosing to support AEs management
  • Indication

Lynparza integrated 1L maintenance treatment pathway:1,2

'Lynparza monotherapy dosing regimen 'Lynparza monotherapy dosing regimen

*To be eligible for Lynparza + bevacizumab as maintenance, patients are required to have a complete or partial response to 1L platinum-based chemotherapy plus bevacizumab.1
† The licenced dose of bevacizumab is 15 mg/kg Q3W with carboplatin and paclitaxel for up to six cycles, followed by 15 mg/kg Q3W as a single agent, for a total of up to 22 cycles or until 
unacceptable toxicity, whichever occurs earlier.1,3,4

Lynparza is available in a tablet formulation for convenient, 
twice-daily dosing1

Lynparza + bevacizumab dosing regimen Lynparza + bevacizumab dosing regimen
Lynparza flexible dosing to help manage AEs Lynparza flexible dosing to help manage AEs

Lynparza flexible dosing to help manage AEs Lynparza flexible dosing to help manage AEs

*For concomitant administration with CY3PA inhibitors, or use in patients with hepatic or renal impairments, please consult the Lynparza 100 mg and 150 mg tablet Summary of Product Characteristics.

For more information, explore our resource hub or contact an 
AstraZeneca or MSD representative

Resources

Discover our resources to
support you and your patients

View resources

Contact us

or sign up to our mailing list

Connect here

Lynparza tablets therapeutic indications1

Lynparza tablets are indicated as
monotherapy for:

  • The maintenance treatment of adult patients with advanced (FIGO stages III and IV) BRCA1/2-mutated (germline and/or somatic) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy.
  • The maintenance treatment of adult patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy.

Lynparza in combination with bevacizumab
is indicated for:

  • The maintenance treatment of adult patients with advanced (FIGO stages III and IV) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy in combination with bevacizumab and whose cancer is associated with homologous recombination deficiency (HRD) positive status defined by either a BRCA1/2 mutation and/or genomic instability.

Please consult the SmPC for further information before making any prescribing decisions.

1L, first-line; AE, adverse event; aOC, advanced Ovarian Cancer; BRCAm, BRCA1 or BRCA2 mutation; FIGO, Fédération Internationale de Gynécologie et d’Obstétrique; HRD, homologous recombination deficiency; Q3W, every 3 weeks; SmPC, Summary of Product Characteristics.

 

  1. Lynparza (olaparib) Summary of Product Characteristics.
  2. Ray-Coquard I, et al. N Engl J Med. 2023;34:681–692. (plus supplementary appendix).
  3. Avastin (bevacizumab) Summary of Product Characteristics.
  4. Ray-Coquard I, et al. N Engl J Med. 2019;381:2416–2428. (plus supplementary appendix).

GB-73637 | February 2026

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to AstraZeneca by visiting https://contactazmedical.astrazeneca.com/ or by calling ‌‌‌0‌‌‌8‌‌‌‌‌0‌‌‌‌0‌‌‌ ‌‌7‌‌‌‌‌‌8‌‌‌3‌‌‌ ‌‌0‌‌‌‌‌0‌‌‌‌3‌‌‌‌3‌‌‌.

Connessiallasalute.it
Connessiallasalute.it

This website was created for UK HCPs and has been designed to provide information to educate, empower and enable them in the great work they are doing for patients across a range of therapy areas. This website is intended for doctors, nurses, and pharmacists in the UK. Other UK residents please visit astrazeneca.co.uk.

Terms of use

Privacy Policy

Cookie Policy

Contact Us

LinkedIn

Twitter

© Merck Sharp & Dohme (UK) Limited 2025. All rights reserved.

©2026 AstraZeneca. GB-73125 | January 2026