Welcome to this UK AstraZeneca produced and funded website
This website is intended for UK Healthcare Professionals only.
The website contains both promotional and non-promotional content.
If you are a patient or a carer of a patient prescribed an AstraZeneca product, please visit myazmed.co.uk
For any other UK residents please visit astrazeneca.co.uk
This website is intended for UK Healthcare Professionals only. Other UK residents please visit astrazeneca.co.uk.
Androgens are essential to prostate function and promote the growth of both normal and cancerous prostate cells by binding to and activating the androgen receptor.
Reducing androgen production by the testis is a therapeutic approach to blocking the production or use of androgen, know as androgen deprivation therapy (ADT). This includes:
ZOLADEX, is a synthetic analogue of naturally occurring LHRH. On chronic administration, ZOLADEX results in inhibition of pituitary LH secretion leading to a fall in serum testosterone concentrations in males
A 2018 systematic review of 16 studies on the clinical differences and treatment of LHRH agonists goserelin, triptorelin and leuprorelin for prostate cancer concluded:
In the absence of robust comparative survival and toxicity data, direct comparisons between products should not be made. Consider a LHRH agonist supported by clinical evidence and the longest follow up in randomised phase 3 trials in high-risk localised and locally advanced
prostate cancer.8-11
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to AstraZeneca by visiting https://contactazmedical.astrazeneca.com/ or by calling 0800 783 0033.
GB-72077 | April 2026
This website was created for UK HCPs and has been designed to provide information to educate, empower and enable them in the great work they are doing for patients across a range of therapy areas. This website is intended for doctors, nurses, and pharmacists in the UK. Other UK residents please visit astrazeneca.co.uk.
