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Prescribing Information Tezspire®▼(tezepelumab)
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TEZSPIRE® (tezepelumab) and lung function
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TEZSPIRE® (tezepelumab) and lung function

 

See full indication

 

A greater improvement in pre-BD FEV1 was observed at week 2 and sustained over 52 weeks with TEZSPIRE vs placebo1,2

Improvement in lung function vs placebo

Key secondary endpoint of NAVIGATOR: pre-BD FEV1 vs placebo1-2:

lung_function_data_image

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Lung function improvement was 
observed at Week 2 and maintained over 52 weeks of treatment 


(160 mL from baseline at Week 2; 230 mL 
from baseline at Week 52)1-2

Adapted from Menzies-Gow A, et al. NEJM. 2021.

  • Patients enrolled with high and low key clinical biomarker levels (bEOS, IgE, or FeNO).1-2
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Improves health-related

quality of life vs placebo

Clinically meaningful improvements in health-related 
quality of life and control of asthma.2,3

Explore Now

TEZSPIRE (tezepelumab) is indicated as an add-on maintenance treatment in adults and adolescents 12 years and older with severe asthma who are inadequately controlled despite high dose inhaled corticosteroids plus another medicinal product for maintenance treatment1

BD=bronchodilator; CI=confidence interval; FeNO=fractional exhaled nitric oxide; FEV1=forced expiratory volume in the first second; IgE=immunoglobulin E; LS=least squares.

 

  1. Tezspire (tezepelumab). Summary of Product Characteristics. 2022. Available at: https://www.medicines.org.uk/emc/product/14064/smpc (last accessed: November 2024).
  2. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809.
  3. Menzies-Gow A, Corren J, Bourdin A, et al. Supplementary Appendix. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809.

GB-56887 | November 2024

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