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Prescribing Information Tezspire®▼(tezepelumab)
Adverse Event Reporting
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TEZSPIRE® (tezepelumab): Efficacy | Quality of Life Data
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TEZSPIRE® (tezepelumab): health-related quality 
of life

 

See full indication

 

TEZSPIRE observed improvements in asthma control, asthma quality of life and asthma symptoms vs placebo1,2

The minimal clinically important difference for the ACQ-6, ASD, and AQLQ(S)+12 scores is 0.5 points change from baseline.

Improves asthma quality of life vs placebo

Secondary endpoint of NAVIGATOR: Asthma Quality of Life Questionnaire (AQLQ(S))+12 score change from baseline1,2

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Improves asthma control vs placebo

Secondary endpoint of NAVIGATOR: Asthma Control Questionnaire-6 (ACQ-6) change from baseline1,2

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Final PRO asthma

Secondary endpoint: Asthma Symptoms Diary (ASD) overall score

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*The ASD comprises of 10 asthma symptoms and activity terms: 5 items in the morning and 5 items in the evening. ASD ranges from 0 (no symptoms) to 4 (worst possible symptoms). The score is the mean of the 10 items1,2

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Efficacy across phenotypes
and irrespective of key clinical
biomarker levels†,1,3-9

See severe asthma patient profiles.

Explore Now

†Eosinophilic and non-eosinophilic, allergic and non-allergic; irrespective of biomarkers (bEOS, IgE or FeNO).

TEZSPIRE (tezepelumab) is indicated as an add-on maintenance treatment in adults and adolescents 12 years and older with severe asthma who are inadequately controlled despite high dose inhaled corticosteroids plus another medicinal product for maintenance treatment3

ACQ-6=asthma control questionnaire-6; AQLQ(S)+12=standardised asthma quality of life questionnaire for 12 years and older; ASD=asthma symptom diary; bEOS=blood eosinophils; CI=confidence interval; FeNO=fractional exhaled nitric oxide; IgE=immunoglobulin E; LS=least squares; PRO=patient reported outcomes.

 

  1. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809.
  2. Menzies-Gow A, Corren J, Bourdin A, et al. Supplementary Appendix. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800-1809.
  3. Tezspire (tezepelumab). Summary of Product Characteristics. 2022. Available at: https://www.medicines.org.uk/emc/product/14064/smpc (last accessed: November 2024).
  4. Corren J, Parnes JR, Wang L, et al. Tezepelumab in adults with uncontrolled asthma. N Engl J Med. 2017;377(10):936-946.
  5. Nucala (mepolizumab). Summary of Product Characteristics. 2022. Available at: https://www.medicines.org.uk/emc/product/10563/smpc (last accessed: November 2024).
  6. Cinqaero (reslizumab). Summary of Product Characteristics. 2022. Available at: https://www.medicines.org.uk/emc/product/4370/smpc (last accessed: November 2024).
  7. Fasenra (Benralizumab). Summary of Product Characteristics. 2023. Available at: https://www.medicines.org.uk/emc/product/10559/smpc (last accessed: November 2024).
  8. Dupixent (dupilumab). Summary of Product Characteristics. 2023. Available at: https://www.medicines.org.uk/emc/product/8553/smpc (last accessed: November 2024).
  9. Xolair (omalizumab). Summary of Product Characteristics. 2022. Available at: https://www.medicines.org.uk/emc/product/4725/smpc (last accessed: November 2024).

GB-56889 | November 2024

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Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to AstraZeneca by visiting https://contactazmedical.astrazeneca.com/ or by calling ‌‌‌0‌‌‌8‌‌‌‌‌0‌‌‌‌0‌‌‌ ‌‌7‌‌‌‌‌‌8‌‌‌3‌‌‌ ‌‌0‌‌‌‌‌0‌‌‌‌3‌‌‌‌3‌‌‌.

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